Clopidogrel-induced hepatotoxicity.
نویسندگان
چکیده
منابع مشابه
Clopidogrel-induced hepatotoxicity after percutaneous coronary stenting.
Clopidogrel, an adenosine diphosphate receptor blocker, is widely used as an adjunctive antiplatelet therapy in acute coronary syndrome and percutaneous coronary stenting. The occurrence of hepatotoxicity is rare. We describe the occurrence of symptomatic liver disease in a 74-year-old man 5 weeks following commencement of therapy with clopidogrel. The reported cases of clopidogrel-induced hepa...
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Clopidogrel is an irreversible antiplatelet agent belonging to the thienopyridine group that acts to antagonize the adenosine diphosphate P2Y12 receptor on platelets. It thus inhibits the activation of platelet glycoprotein GPIIb/IIIa complex, which is essential for fibrinogen—platelet complex formation. Clopidogrel has widely replaced ticlopidine because of a much better clinical safety profil...
متن کاملClopidogrel-Induced Severe Hepatitis: A Case Report and Literature Review
Clopidogrel is a commonly prescribed antiplatelet agent that carries a rare risk of hepatotoxicity. We describe a case of severe clopidogrel-induced hepatitis with liver biopsy assessment. Prompt recognition and withdrawal of the offending agent are imperative to prevent progression and potentially fatal liver injury.
متن کاملModulation of miR-26a-5p and miR-15b-5p Exosomal Expression Associated with Clopidogrel-Induced Hepatotoxicity in HepG2 Cells
Clopidogrel is an essential antiplatelet drug used to prevent thrombosis complications associated with atherosclerosis. However, hepatotoxicity is a potential adverse effect related to clopidogrel therapy. Exosome-derived miRNAs may be useful for improved monitoring of drug response and hepatotoxicity risk. In the present study, the expression of several exosomal miRNAs (miR-26a-5p, miR-145-5p,...
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1. Jarvis B, Simpson K. Clopidogrel: a review of its use in the prevention of a atherothrombosis. Drugs. 2000;60:347-77. 2. Wolf I, Mouallem M, Rath S, Farfel Z. Clopidogrel-induced systemic inflammatory response syndrome. Mayo Clin Proc. 2003;78:618-20. 3. Lee WM. Drug-induced hepatotoxicity. N Engl J Med. 2003;349: 474-85. 4. María VAJ, Victorino RMM. Development and validation of a clinical ...
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عنوان ژورنال:
- Journal of postgraduate medicine
دوره 54 2 شماره
صفحات -
تاریخ انتشار 2008